This book contains all refereed papers that were accepted to the “Complex Systems Design & Management” (CSDM 2010) international conference that took place in Paris (France), October 27 – 29, 2010 (Website: http://www.csdm2010.csdm.fr). These proceedings covers the most recent trends in the emerging field of complex systems sciences & practices from an industrial and academic perspective, including the main industrial domains (transport, defense & security, electronics, energy & environment, health, communications & media, e-services), scientific & technical topics (systems fundamentals, systems architecture & engineering, systems metrics & quality, systemic tools) and system types (transportation systems, embedded systems, software & information systems, systems of systems, artificial ecosystems). The CSDM 2010 conference is organized under the guidance of the CESAMES non profit organization (Website: http://www.cesames.net).